Nitrones as therapeutics
نویسندگان
چکیده
منابع مشابه
Nitrones, their value as therapeutics and probes to understand aging.
The nitrone-based free radical traps have significant potential in the treatment of neurodegenerative diseases as well as in the prolongation of life span. The mass action free radical trapping activity of these compounds is the property, which first brought them to the attention of the scientific community. Nevertheless extensive research has demonstrated that these reactions are not responsib...
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Specific nitrones have been used for more than 30 years in analytical chemistry and biochemistry to trap and stabilize free radicals for the purpose of their identification and characterization. PBN (alpha-phenyl-tert-butyl nitrone), one of the more widely used nitrones for this purpose, has been shown to have potent pharmacologic activities in models of a number of aging-related diseases, most...
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[This corrects the article on p. 281 in vol. 8, PMID: 27932976.].
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Proteases are an expanding class of drugs that hold great promise. The U.S. FDA (Food and Drug Administration) has approved 12 protease therapies, and a number of next generation or completely new proteases are in clinical development. Although they are a well-recognized class of targets for inhibitors, proteases themselves have not typically been considered as a drug class despite their applic...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2008
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2008.08.017